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G Protein‐Coupled Receptor Activation: Amino Acid Movements Caught Infra‐Red‐Handed
Author(s) -
Hoffmann Carsten
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000502
Subject(s) - phenylalanine , amino acid , receptor , chemistry , g protein coupled receptor , mechanism (biology) , biochemistry , stereochemistry , biophysics , computational biology , biology , physics , quantum mechanics
Taking up position: Due to the importance of G protein‐coupled receptors as drug targets, their mechanism of activation is a major research interest. The recently developed AMBER stop codon suppression technology allows detailed insights into this process by use of p ‐azido‐ L ‐phenylalanine (azidoF) protein modification and FTIR analysis.