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Mechanism(s) of SWI/SNF‐Induced Nucleosome Mobilization
Author(s) -
Liu Ning,
Balliano Angela,
Hayes Jeffrey J.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000455
Subject(s) - swi/snf , nucleosome , histone , chromatin remodeling , chromatin , atp hydrolysis , dna , microbiology and biotechnology , chromatin structure remodeling (rsc) complex , mechanism (biology) , chemistry , biology , biophysics , computational biology , biochemistry , enzyme , atpase , physics , quantum mechanics
Impediments to DNA access due to assembly of the eukaryotic genome into chromatin are in part overcome by the activity of ATP‐dependent chromatin‐remodeling complexes. These complexes employ energy derived from ATP hydrolysis to destabilize histone—DNA interactions and alter nucleosome positions, thereby increasing the accessibility of DNA‐binding factors to their targets. However, the mechanism by which theses complexes accomplish this task remains unresolved. We review aspects of nucleosome alteration by the SWI/SNF complex, the archetypal remodeling enzyme. We focus on experiments that provide insights into how SWI/SNF induces nucleosome movement along DNA. Numerous biochemical activities have been characterized for this complex, all likely providing clues as to the molecular mechanism of translocation.