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Elucidation of the Biosynthesis and Degradation of Allantofuranone by Isotopic Labelling and Fermentation of Modified Precursors
Author(s) -
Schüffler Anja,
Liermann Johannes C.,
Opatz Till,
Anke Timm
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000448
Subject(s) - biosynthesis , labelling , fermentation , degradation (telecommunications) , biochemistry , chemistry , isotopic labeling , phenylalanine , abiotic component , stereochemistry , biology , organic chemistry , amino acid , enzyme , telecommunications , paleontology , computer science
Feeding experiments with the ascomycete Allantophomopsis lycopodina indicated that the potent fungistatic allantofuranone is biosynthesized from phenylalanine. Further experiments with synthetic precursors gave evidence that the naturally occurring polyporic acid serves as a key intermediate in the biosynthesis. In addition to the formation of allantofuranone, its abiotic and metabolic degradation were investigated.