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An Engineered DNA‐Binding Protein Self‐assembles Metallic Nanostructures
Author(s) -
Hall Sedlak Ruth,
Hnilova Marketa,
Gachelet Eliora,
Przybyla Laralynne,
Dranow David,
Gonen Tamir,
Sarikaya Mehmet,
Tamerler Candan,
Traxler Beth
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000407
Subject(s) - bifunctional , dna , nanotechnology , dna origami , peptide , molecular engineering , protein engineering , nanostructure , self assembly , dna nanotechnology , chemistry , materials science , biochemistry , enzyme , catalysis
The golden age of DNA: We describe a strategy for engineering bifunctional proteins that simultaneously associate with metals and DNA to create self‐assembled nanostructures. A DNA binding protein engineered with a gold binding peptide arranges colloidal gold particles along a DNA guide by virtue of its introduced peptide motif. These self‐assembled complexes represent a step toward constructing nanoarchitectures with potential in nanoelectronic and photonic devices.