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Glucosamine‐6‐sulfamate Analogues of Heparan Sulfate as Inhibitors of Endosulfatases
Author(s) -
Schelwies Mathias,
Brinson Diana,
Otsuki Shuhei,
Hong YoungHoon,
Lotz Martin K.,
Wong ChiHuey,
Hanson Sarah R.
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000401
Subject(s) - library science , humanities , art , computer science
Keeping sulfate: The extracellular endosulfatases, which modulate signaling pathways by removing sulfate groups from heparan sulfate can be inhibited by replacing the 6‐sulfate destined for cleavage with an inhibitory sulfamate motif. Glucosamine‐6‐sulfamate analogues demonstrate biochemical inhibition and utility as tools to understand the biological and therapeutic relevance of the endosulfatases.