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Multifaceted Modes of Action for the Glutarimide‐Containing Polyketides Revealed
Author(s) -
Rajski Scott R.,
Shen Ben
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000370
Subject(s) - cytotoxicity , mode of action , chemistry , computational biology , intracellular , stereochemistry , biochemistry , biology , in vitro
Recent advances in our understanding of cell‐migration inhibition and cytotoxicity of the glutarimide‐containing polyketides are highlighted. Independent mode of action studies now make it possible to correlate specific structural features to specific intracellular binding interactions and their downstream results.