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Analysis of the Sorangicin Gene Cluster Reinforces the Utility of a Combined Phylogenetic/Retrobiosynthetic Analysis for Deciphering Natural Product Assembly by trans ‐AT PKS
Author(s) -
Irschik Herbert,
Kopp Maren,
Weissman Kira J.,
Buntin Kathrin,
Piel Jörn,
Müller Rolf
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000313
Subject(s) - polyketide , natural product , phylogenetic tree , gene cluster , computational biology , biosynthesis , product (mathematics) , biology , gene , information retrieval , computer science , genetics , biochemistry , geometry , mathematics
A useful strategy: Deciphering biosynthesis by trans ‐AT polyketide synthases (PKS) is challenging due to their highly nonlinear organization. Our analysis of the trans ‐AT PKS responsible for sorangicin production in the myxobacterium Sorangium cellulosum So ce12 reinforces the utility of a combined phylogenetic/retrobiosynthetic approach for understanding this complex mode of biosynthesis.