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Site‐Specific Cytosine to Uracil Transition by Using Reversible DNA Photo‐crosslinking
Author(s) -
Fujimoto Kenzo,
KonishiHiratsuka Kaoru,
Sakamoto Takashi,
Yoshimura Yoshinaga
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000274
Subject(s) - deamination , cytosine , uracil , dna , transition (genetics) , chemistry , nucleoside , computer science , biochemistry , computational biology , biology , gene , enzyme
Targeting a single cytosine in the presence of others: The deamination coupled with 3‐cyanovinylcarbazole‐nucleoside‐mediated photo‐crosslinking allows heat‐induced conversion of cytosine into uracil with high site‐specificity and without side reactions.