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Nucleating the Assembly of Macromolecular Complexes
Author(s) -
PetersonKaufman Kimberly J.,
Carlson Clayton D.,
RodríguezMartínez José A.,
Ansari Aseem Z.
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000255
Subject(s) - macromolecule , chemistry , macromolecular substances , nanotechnology , combinatorial chemistry , materials science , biochemistry
Nature constructs intricate complexes containing numerous binding partners in order to direct a variety of cellular processes. Researchers have taken a cue from these events to develop synthetic molecules that can nucleate natural and unnatural interactions for a diverse set of applications. These molecules can be designed to drive protein dimerization or to modulate the interactions between proteins, lipids, DNA, or RNA and thereby alter cellular pathways. A variety of components within the cellular machinery can be recruited with or replaced by synthetic compounds. Directing the formation of multicomponent complexes with new synthetic molecules can allow unprecedented control over the cellular machinery.