Development of a DNA Photoaffinity Probe for the Analysis of 8‐OxodG‐Binding Proteins in a Human Proteome | Zendy

Winnacker Malte | Zendy; Welzmiller Veronika | Zendy; Strasser Ralf | Zendy; Carell Thomas | Zendy

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Development of a DNA Photoaffinity Probe for the Analysis of 8‐OxodG‐Binding Proteins in a Human Proteome

Author(s) -

Winnacker Malte,

Welzmiller Veronika,

Strasser Ralf,

Carell Thomas

Publication year - 2010

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201000244

Subject(s) - photoaffinity labeling , proteome , dna , computational biology , dna repair , human proteome project , chemistry , dna mismatch repair , biochemistry , biology , binding site , proteomics , gene

Finding DNA repair factors: A comparative study with DNA probes containing 8‐oxodG and bearing different photo‐crosslinking moieties found that a triethyleneglycol‐trifluoromethyl‐phenyldiazirine system was excellent for the labeling of DNA repair factors. This probe was used for the activity‐based and selective labeling of different DNA repair factors in a human HCT‐116 nuclear proteome.

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