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Azole‐Based Cyclic Peptides from the Sea Squirt Lissoclinum Patella : Old Scaffolds, New Avenues
Author(s) -
Houssen Wael E.,
Jaspars Marcel
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000230
Subject(s) - cyclic peptide , gene cluster , azole , biology , gene , computational biology , ribosomal rna , chemistry , stereochemistry , genetics , biochemistry , peptide , microbiology and biotechnology , antifungal
A combinatorial library encoded on a single gene: Azole‐based cyclic peptides identified from the marine ascidian Lissoclinum patella are produced by its cyanobacterial symbiont Prochloron sp. through a ribosomal pathway. Variants of a single gene within the biosynthetic cluster led to different products.