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Protease‐Activatable Collagen Targeting Based on Protein Cyclization
Author(s) -
Breurken Monika,
Lempens Edith H. M.,
Merkx Maarten
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000223
Subject(s) - triple helix , extracellular matrix , protease , chemistry , computational biology , threading (protein sequence) , sequence (biology) , biochemistry , computer science , combinatorial chemistry , protein structure , biology , stereochemistry , enzyme
Threading collagen through a protein needle: The collagen‐binding protein CNA35 operates by wrapping itself around the collagen triple helix. By connecting the N and C termini through an MMP recognition sequence, a dual‐specific MMP‐sensitive collagen‐targeting ligand is obtained that can be used for imaging extracellular matrix turnover.