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Engineered DNA Polymerases in Biotechnology
Author(s) -
Kranaster Ramon,
Marx Andreas
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000215
Subject(s) - dna polymerase , polymerase , computational biology , biology , dna , genetics
The latest polymerases: New DNA sequencing technologies, smart PCR strategies and reliable pathogen‐detection assays most frequently rely on the performance of DNA polymerases. Directed enzyme evolution and rational design are the key steps to developing highly specialised, custom‐made DNA polymerase variants. Recent achievements are reviewed.