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The α/β‐Hydrolase Fold 3DM Database (ABHDB) as a Tool for Protein Engineering
Author(s) -
Kourist Robert,
Jochens Helge,
Bartsch Sebastian,
Kuipers Remko,
Padhi Santosh Kumar,
Gall Markus,
Böttcher Dominique,
Joosten HenkJan,
Bornscheuer Uwe T.
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000213
Subject(s) - haystack , protein engineering , superfamily , fold (higher order function) , hydrolase , directed evolution , database , computational biology , enzyme , computer science , chemistry , biology , biochemistry , world wide web , gene , mutant , programming language
Aligning the haystack to expose the needle: The 3DM method was used to generate a comprehensive database of the α/β‐hydrolase fold enzyme superfamily. This database facilitates the analysis of structure–function relationships and enables novel insights into this superfamily to be made. In addition high‐quality libraries for protein engineering can be easily designed.