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Translesion Synthesis of 1,3‐GTG Cisplatin DNA Lesions
Author(s) -
Schneider Sabine,
Reißner Thomas,
Ziv Omer,
Livneh Zvi,
Carell Thomas
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000211
Subject(s) - cisplatin , dna polymerase , polymerase , dna damage , dna , dna synthesis , dna polymerase beta , biology , microbiology and biotechnology , chemistry , genetics , chemotherapy , base excision repair
Low‐fidelity polymerases: Cells can copy genetic material even in the presence of DNA lesions. Here we show that this bypass process is also possible for the strongly helix disturbing cisplatin 1,3‐GTG lesion. A key polymerase involved in the translesion synthesis (TLS) process is Pol η. The results have implication for the resistance problem associated with cisplatin chemotherapy.