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Delivery of Oligonucleotides and Analogues: The Oligonucleotide Conjugate‐Based Approach
Author(s) -
Marlin Fanny,
Simon Philippe,
SaisonBehmoaras Tula,
Giovannangeli Carine
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000138
Subject(s) - oligonucleotide , conjugate , computational biology , nanotechnology , chemistry , combinatorial chemistry , biology , biochemistry , materials science , dna , mathematical analysis , mathematics
Carrier conjugates: Oligonucleotide‐based therapeutic strategies are moving closer to use in patients, but bench work is still needed. Although oligonucleotides are validated and powerful tools in basic research, their delivery is still the major issue impeding their use as therapeutics. Carrier–oligonucleotide conjugates currently in development are reviewed here.