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Bioluminescent Probes of Sulfatase Activity
Author(s) -
Rush Jason S.,
Beatty Kimberly E.,
Bertozzi Carolyn R.
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000115
Subject(s) - sulfatase , bioluminescence , enzyme , computational biology , computer science , luciferase , biochemistry , modalities , modulation (music) , chemistry , information retrieval , biology , physics , gene , sociology , acoustics , transfection , social science
Lighting up sulfatases: A panel of bioluminescent sulfatase reporters have been developed that can be used to investigate sulfatase activity in both human and prokaryotic cell samples. Structural modulation allowed selective probe activation by particular enzymes. This strategy has potential application in common clinical imaging modalities, such as MRI and PET.