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Two Functions, One Molecule: A Metal‐Binding and a Targeting Moiety to Combat Alzheimer's Disease
Author(s) -
Hureau Christelle,
Sasaki Isabelle,
Gras Emmanuel,
Faller Peter
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000102
Subject(s) - pharmacophore , moiety , oxidative stress , peptide , chemistry , amyloid (mycology) , combinatorial chemistry , small molecule , chelation , biochemistry , biophysics , stereochemistry , biology , organic chemistry , inorganic chemistry
Merging pharmacophores : Aggregation of the peptide amyloid‐β (Aβ) is responsible for the development of Alzheimer's disease. Metal ions bound to Aβ can promote aggregation and oxidative stress, and can thus have a detrimental effect. Disruption of these processes with chelators, as well as targeting these chelators towards Aβ aggregates is therefore a promising strategy.
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