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Developing High‐Affinity Boron‐Based Receptors for Cell‐Surface Carbohydrates
Author(s) -
Houston Todd A.
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000079
Subject(s) - boron , receptor , cell surface receptor , biochemistry , chemistry , cell , carbohydrate , biophysics , new horizons , competition (biology) , microbiology and biotechnology , nanotechnology , biology , organic chemistry , materials science , ecology , engineering , spacecraft , aerospace engineering
The rich history of research into boron–carbohydrate interactions has, unfortunately, not translated into many examples of boron‐based receptors for cell‐surface sugars. However, a recent breakthrough by Hall has shown that hexoses can be targeted with boroxole‐based systems ( 1 ) that show selective binding of the TF antigen in competition with natural lectins.