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Guanine, Adenine, and Hypoxanthine Production in UV‐Irradiated Formamide Solutions: Relaxation of the Requirements for Prebiotic Purine Nucleobase Formation
Author(s) -
Barks Hannah L.,
Buckley Ragan,
Grieves Gregory A.,
Di Mauro Ernesto,
Hud Nicholas V.,
Orlando Thomas M.
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000074
Subject(s) - nucleobase , hypoxanthine , prebiotic , guanine , formamide , purine , chemistry , irradiation , biochemistry , combinatorial chemistry , organic chemistry , nucleotide , dna , physics , nuclear physics , gene , enzyme
Relaxed requirements: We demonstrate the formation of adenine, hypoxanthine, and guanine from heated (130 °C), UV‐irradiated formamide solutions in the absence of an inorganic catalyst. Evidence is also provided that “classical” HCN pathways for purine nucleobase production are also active in heated and UV‐irradiated formamide reactions.