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DNA‐Encoded Chemical Libraries: A Tool for Drug Discovery and for Chemical Biology
Author(s) -
Scheuermann Jörg,
Neri Dario
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000066
Subject(s) - drug discovery , oligonucleotide , dna , chemical biology , computational biology , dna sequencing , chemical library , genomic library , biology , nanotechnology , combinatorial chemistry , chemistry , genetics , small molecule , bioinformatics , base sequence , materials science
DNA decoder: The collection of organic molecules, individually coupled to distinctive oligonucleotides, is generally referred to as “DNA‐encoded chemical library”. In full analogy to phage display technology, these libraries can be panned on immobilized target proteins and analyzed (before and after selection) by suitable “decoding” methods (for example, DNA‐sequencing).