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A Step Closer to Complete Chemical Reprogramming for Generating iPS Cells
Author(s) -
Solanki Aniruddh,
Lee Ki Bum
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000032
Subject(s) - reprogramming , sox2 , induced pluripotent stem cell , somatic cell , transcription factor , klf4 , chemical biology , biology , microbiology and biotechnology , transgene , chemistry , genetics , embryonic stem cell , cell , gene
The chemical approach: To overcome the problems involved in using viral vectors and transgenes to generate induced pluripotent stem cells, Ichida et al., have discovered a small molecule, RepSox, that successfully replaces the transcription factor Sox2 in reprogramming somatic cells into iPSCs by inhibiting transforming growth factor‐β signaling.