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Chemical and Chemoenzymatic Synthesis of Glycopeptide Selectin Ligands Containing Sialyl Lewis X Structures
Author(s) -
Pudelko Maciej,
Bull James,
Kunz Horst
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000029
Subject(s) - selectin , glycopeptide , sialyl lewis x , chemistry , glycobiology , biochemistry , cell adhesion , receptor , glycoprotein , stereochemistry , adhesion , glycan , cell , organic chemistry , antibiotics
Carbohydrates play essential roles in various cell‐adhesion events, such as between Lewis saccharides and carbohydrate‐recognising proteins: the selectins. This article provides an overview of recent syntheses of glycopeptide selectin ligands, including carbohydrate motifs and scaffold modifications that might improve the affinity of these structures for receptors.