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Mechanisms of RNA Degradation by the Eukaryotic Exosome
Author(s) -
Tomecki Rafal,
Drazkowska Karolina,
Dziembowski Andrzej
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000025
Subject(s) - exosome complex , rna , exosome , microbiology and biotechnology , protein subunit , biology , computational biology , microvesicles , chemistry , biochemistry , non coding rna , microrna , gene
RNA on its way to destruction: The exosome is a multi‐subunit protein complex involved in essentially all phenomena associated with RNA metabolism in eukaryotic cells. This review discusses recent discoveries in the fields of biochemistry and structural biology that have shed new light on the mechanisms of RNA recruitment to the catalytic subunits of the exosome.