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Activation Instead of Inhibition: Targeting Proenzymes for Small‐Molecule Intervention
Author(s) -
Ottmann Christian,
Hauske Patrick,
Kaiser Markus
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000024
Subject(s) - proteases , small molecule , microbiology and biotechnology , biology , chemistry , computational biology , biochemistry , enzyme
Switching on pro‐proteases: Direct small‐molecule activation of proenzymes such as pro‐proteases has recently be achieved for procaspase‐3. This success opens up new possibilities for small‐molecule intervention in biology, and reveals proenzymes as a whole new class of potential targets.