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Inside Cover: A Fragment‐Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry (ChemBioChem 17/2009)
Author(s) -
Scott Duncan E.,
Dawes Gwen J.,
Ando Michiyo,
Abell Chris,
Ciulli Alessio
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200990077
Subject(s) - cover (algebra) , fragment (logic) , chemistry , combinatorial chemistry , ligand (biochemistry) , stereochemistry , computer science , biochemistry , algorithm , engineering , receptor , mechanical engineering
The inside cover picture shows the active site of pantothenate synthetase templating a dynamic combinatorial library of disulfides. Library members were formed dynamically between anchor ligand 5′‐deoxy‐5′‐thioadenosine and thiol fragments to probe interactions in adjacent pockets. The best binder was identified by HPLC analysis and confirmed by X‐ray crystallography. For more information, see the paper by A. Ciulli, C. Abell et al. on p. 2772 ff.