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Inside Cover: Syringolin A Selectively Labels the 20 S Proteasome in Murine EL4 and Wild‐Type and Bortezomib‐Adapted Leukaemic Cell Lines (ChemBioChem 16/2009)
Author(s) -
Clerc Jérôme,
Florea Bogdan I.,
Kraus Marianne,
Groll Michael,
Huber Robert,
Bachmann André S.,
Dudler Robert,
Driessen Christoph,
Overkleeft Herman S.,
Kaiser Markus
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200990072
Subject(s) - moiety , proteasome , bortezomib , cover (algebra) , chemistry , natural product , rhodamine , fluorescence , biophysics , biochemistry , microbiology and biotechnology , biology , stereochemistry , immunology , physics , mechanical engineering , quantum mechanics , engineering , multiple myeloma
The inside cover picture shows the plant‐pathogen‐derived natural product Syringolin A, which was turned into an activity‐based probe by attaching a fluorescent rhodamine moiety. This probe was then used to shed light on the labelling specificity of Syringolin A, demonstrating a highly specific binding to the eukaryotic 20S proteasome. For further details, see the article by M. Kaiser et al. on p. 2638 ff.