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Inside Cover: Molecular Basis for the Stereoselective Ammoniolysis of N ‐Alkyl Aziridine‐2‐Carboxylates Catalyzed by Candida antarctica Lipase B (ChemBioChem 13/2009)
Author(s) -
Park JaeHoon,
Ha HyunJoon,
Lee Won Koo,
GénéreuxVincent Tobie,
Kazlauskas Romas J.
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200990054
Subject(s) - candida antarctica , aziridine , cover (algebra) , stereoselectivity , lipase , enantiomer , chemistry , alkyl , stereochemistry , catalysis , enzyme , organic chemistry , ring (chemistry) , engineering , mechanical engineering
The inside cover picture shows that the wrong hand can fit into a glove in two different ways. Recognizing the incorrect fit requires different mechanisms: 1) fingers mismatched or 2) palm curl incorrect. Similarly, the wrong enantiomer can fit into an enzyme's active site in different ways and require different mechanisms for high enantioselectivity. For more information, see the article by R. J. Kazlauskas et al. on p. 2213 ff.