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Inside Cover: Disruption of Transcriptionally Active Stat3 Dimers with Non‐phosphorylated, Salicylic Acid‐Based Small Molecules: Potent in vitro and Tumor Cell Activities (ChemBioChem 12/2009)
Author(s) -
Fletcher Steven,
Singh Jardeephi,
Zhang Xiaolei,
Yue Peibin,
Page Brent D. G.,
Sharmeen Sumaiya,
Shahani Vijay M.,
Zhao Wei,
Schimmer Aaron D.,
Turkson James,
Gunning Patrick T.
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200990048
Subject(s) - salicylic acid , in vitro , chemistry , stat3 , phosphorylation , small molecule , drug discovery , cover (algebra) , rational design , combinatorial chemistry , computational biology , microbiology and biotechnology , biochemistry , stereochemistry , cancer research , biology , genetics , mechanical engineering , engineering
The inside cover picture shows the culmination of a rational drug discovery program of Stat3 inhibitors. Computational modeling of the most potent salicylic acid‐based therapeutic shows excellent occupation of the Stat3‐SH2 domain, thereby inhibiting its homodimerization. For details, see the communication by P. T. Gunning et al. on p. 1959 ff.