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Cover Picture: Identification of Flavopiridol Analogues that Selectively Inhibit Positive Transcription Elongation Factor (P‐TEFb) and Block HIV‐1 Replication (ChemBioChem 12/2009)
Author(s) -
Ali Akbar,
Ghosh Animesh,
Nathans Robin S.,
Sharova Natalia,
O'Brien Siobhan,
Cao Hong,
Stevenson Mario,
Rana Tariq M.
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200990047
Subject(s) - p tefb , rna polymerase ii , biology , microbiology and biotechnology , elongation factor , cyclin dependent kinase 9 , rna , gene , transcription (linguistics) , small hairpin rna , gene expression , genetics , virology , chemistry , cyclin dependent kinase 2 , promoter , cell cycle , ribosome , linguistics , philosophy
The cover picture shows how a specific inhibitor of CDK9 could regulate HIV‐1 replication. The HIV‐1 genome is integrated into a human chromosome and is transcribed by RNA polymerase II. For active viral gene expression, the HIV‐1 regulatory factor Tat binds a structured RNA hairpin loop of early nascent transcript, termed TAR RNA, and recruits a host heterodimer kinase complex containing cyclinT1 and CDK9. A selective and potent inhibitor of CDK9 blocks HIV‐1 gene expression. For more details see the article on by T. M. Rana et al. on p. 2072 ff. Cover illustrated by Drs. Huricha Baigude and Chia‐Ying Chu.