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Chemical Protein Synthesis by Kinetically Controlled Ligation of Peptide O‐Esters
Author(s) -
Zheng JiShen,
Cui HongKui,
Fang GeMin,
Xi WeiXian,
Liu Lei
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900789
Subject(s) - peptide , ligation , chemical ligation , combinatorial chemistry , chemistry , condensation , reactivity (psychology) , native chemical ligation , biochemistry , chemical synthesis , biology , microbiology and biotechnology , medicine , physics , alternative medicine , in vitro , pathology , thermodynamics
Designer peptides: A large reactivity difference was observed between two peptide O‐esters that can undergo peptide ligation through an in situ O‐to‐S acyl shift. This observation allowed for the design of “one‐pot” N‐to‐C sequential peptide fragment condensation through kinetically controlled ligation with more readily accessible peptide O‐esters.