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The Future of Aminoglycosides: The End or Renaissance?
Author(s) -
Houghton Jacob L.,
Green Keith D.,
Chen Wenjing,
GarneauTsodikova Sylvie
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900779
Subject(s) - ingenuity , the renaissance , toxicity , class (philosophy) , computational biology , biology , computer science , medicine , history , philosophy , epistemology , artificial intelligence , art history
Although aminoglycosides have been used as antibacterials for decades, their use has been hindered by their inherent toxicity and the resistance that has emerged to these compounds. It seems that such issues have relegated a formerly front‐line class of antimicrobials to the proverbial back shelf. However, recent advances have demonstrated that novel aminoglycosides have a potential to overcome resistance as well as to be used to treat HIV‐1 and even human genetic disorders, with abrogated toxicity. It is not the end for aminoglycosides, but rather, the challenges faced by researchers have led to ingenuity and a change in how we view this class of compounds, a renaissance.