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Zinc Fingered: New Compounds that Thwart Gram‐Positive Biofilm Formation by Sequestering Zinc
Author(s) -
Musk Dinty J.
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900691
Subject(s) - biofilm , enterococcus faecium , staphylococcus epidermidis , microbiology and biotechnology , zinc , staphylococcus aureus , chemistry , enterococcus , antimicrobial , staphylococcus , biology , bacteria , antibiotics , organic chemistry , genetics
Gram‐positive biofilms, beware: A new class of small‐molecule biofilm inhibitors functions with significant potency against clinically relevant biofilm‐forming species, including methicillin‐resistant Staphylococcus aureus , vancomycin‐resistant Enterococcus faecium (a VRE), and Staphylococcus epidermidis. The biofilm‐inhibiting compounds, all 2‐aminobenzimidazole (2‐ABI) derivatives, were found to act by sequestering zinc.