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The Biosynthesis of Liposidomycin‐like A‐90289 Antibiotics Featuring a New Type of Sulfotransferase
Author(s) -
Funabashi Masanori,
Baba Satoshi,
aka Koichi,
Hosobuchi Masahiko,
Fujita Yoko,
Shibata Tomoyuki,
Van Lanen Steven G.
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900665
Subject(s) - peptidoglycan , translocase , biochemistry , lipid ii , biosynthesis , nucleoside , antibiotics , biology , bacterial cell structure , enzyme , bacteria , gene , genetics , chromosomal translocation
Lip reading: The biosynthetic gene cluster for A‐90289, a fatty acid nucleoside antibiotic, was cloned and sequenced. The sulfotransferase LipB is demonstrated to be essential for A‐90289 biosynthesis, and in vitro characterization revealed LipB utilizes p ‐nitrophenylsulfate as an aryl sulfate donor and a variety of nonaryl acceptors including caprazamycin A to give the 2′‐ O ‐sulfated product, A‐90289A.