The Biosynthesis of Liposidomycin‐like A‐90289 Antibiotics Featuring a New Type of Sulfotransferase | Zendy

Funabashi Masanori | Zendy; Baba Satoshi | Zendy; aka Koichi | Zendy; Hosobuchi Masahiko | Zendy; Fujita Yoko | Zendy; Shibata Tomoyuki | Zendy; Van Lanen Steven G. | Zendy

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The Biosynthesis of Liposidomycin‐like A‐90289 Antibiotics Featuring a New Type of Sulfotransferase

Author(s) -

Funabashi Masanori,

Baba Satoshi,

aka Koichi,

Hosobuchi Masahiko,

Fujita Yoko,

Shibata Tomoyuki,

Van Lanen Steven G.

Publication year - 2010

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200900665

Subject(s) - peptidoglycan , translocase , biochemistry , lipid ii , biosynthesis , nucleoside , antibiotics , biology , bacterial cell structure , enzyme , bacteria , gene , genetics , chromosomal translocation

Lip reading: The biosynthetic gene cluster for A‐90289, a fatty acid nucleoside antibiotic, was cloned and sequenced. The sulfotransferase LipB is demonstrated to be essential for A‐90289 biosynthesis, and in vitro characterization revealed LipB utilizes p ‐nitrophenylsulfate as an aryl sulfate donor and a variety of nonaryl acceptors including caprazamycin A to give the 2′‐ O ‐sulfated product, A‐90289A.

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