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New Ways of Killing the Beast: Prospects for Inorganic–Organic Hybrid Nanomaterials as Antibacterial Agents
Author(s) -
Bandow Julia E.,
MetzlerNolte Nils
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900628
Subject(s) - singlet oxygen , nanoparticle , porphyrin , nanotechnology , photodynamic therapy , nanomaterials , chemistry , bacteria , combinatorial chemistry , materials science , photochemistry , oxygen , biology , organic chemistry , genetics
Joining forces: New approaches for antibiotic therapy use inorganic nanoparticles loaded with porphyrin photosensitizers. When irradiated with visible light, these nanoparticles produce singlet oxygen, which in turn kills nearby bacteria. Recent studies identify necessary modifications of the nanoparticles for good adherence to the bacterial membrane and explore the potential of this strategy for combating multiresistant bacterial strains.