Five‐Component Cascade Synthesis of Nucleotide Analogues in an Engineered Self‐Immobilized Enzyme Aggregate | Zendy

Scism Robert A. | Zendy; Bachmann Brian O. | Zendy

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Five‐Component Cascade Synthesis of Nucleotide Analogues in an Engineered Self‐Immobilized Enzyme Aggregate

Author(s) -

Scism Robert A.,

Bachmann Brian O.

Publication year - 2010

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200900620

Subject(s) - cascade , chemistry , nucleotide , component (thermodynamics) , enzyme , aggregate (composite) , synthetic biology , combinatorial chemistry , biochemistry , nanotechnology , computational biology , biology , materials science , chromatography , gene , physics , thermodynamics

Pathway in a particle: A five‐enzyme biosynthetic pathway was self‐immobilized to form a single biocatalyst for generation of purine nucleotide analogues from D ‐ribose. This method provides an alternative to engineering biosynthetic pathways in whole cells that obviates problems associated with toxicity, transport and genetic regulation.

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