z-logo
Premium
Five‐Component Cascade Synthesis of Nucleotide Analogues in an Engineered Self‐Immobilized Enzyme Aggregate
Author(s) -
Scism Robert A.,
Bachmann Brian O.
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900620
Subject(s) - cascade , chemistry , nucleotide , component (thermodynamics) , enzyme , aggregate (composite) , synthetic biology , combinatorial chemistry , biochemistry , nanotechnology , computational biology , biology , materials science , chromatography , gene , physics , thermodynamics
Pathway in a particle: A five‐enzyme biosynthetic pathway was self‐immobilized to form a single biocatalyst for generation of purine nucleotide analogues from D ‐ribose. This method provides an alternative to engineering biosynthetic pathways in whole cells that obviates problems associated with toxicity, transport and genetic regulation.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here