Peptoid–Peptide Hybrid Backbone Architectures

Peptidomimetic oligomers and foldamers have received considerable attention for over a decade, with β‐peptides and the so‐called peptoids ( N ‐alkylglycine oligomers) representing prominent examples of such architectures. Lately, hybrid or mixed backbones consisting of both α‐ and β‐amino acids (α/β‐peptides) have been investigated in some detail as well. The present Minireview is a survey of the literature concerning hybrid structures of α‐amino acids and peptoids, including β‐peptoids ( N ‐alkyl‐β‐alanine oligomers), and is intended to give an overview of this area of research within the field of peptidomimetic science.