Chemical Synthesis and Biological Screening of 2‐Aminoimidazole‐Based Bacterial and Fungal Antibiofilm Agents | Zendy

Rogers Steven A. | Zendy; Bero Joseph D. | Zendy; Melander Christian | Zendy

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Chemical Synthesis and Biological Screening of 2‐Aminoimidazole‐Based Bacterial and Fungal Antibiofilm Agents

Author(s) -

Rogers Steven A.,

Bero Joseph D.,

Melander Christian

Publication year - 2010

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200900617

Subject(s) - microbiology and biotechnology , acinetobacter baumannii , candida albicans , enterococcus faecium , biofilm , vibrio vulnificus , staphylococcus epidermidis , staphylococcus aureus , cryptococcus neoformans , candida tropicalis , pseudomonas aeruginosa , biology , enterococcus faecalis , escherichia coli , antimicrobial , chemistry , bacteria , antibiotics , biochemistry , genetics , gene

A collection of 2‐aminoimidazole/triazole amides has been synthesized and screened for antibiofilm activity. This class of small molecules was found to modulate the biofilm activity of Pseudomonas aeruginosa , a multidrug‐resistant strain of Acinetobacter baumannii (MDRAB), a methicillin‐resistant Staphylococcus aureus strain (MRSA), Escherichia coli , Rhodospirillum salexigens , Staphylococcus epidermidis , Vibrio vulnificus , and vancomycin‐resistant Enterococcus faecium as well as the yeast Candida albicans and Cryptococcus neoformans . Furthermore, lead compounds were found to not lyse red blood cells at active concentrations.

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