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Wall Teichoic Acid Function, Biosynthesis, and Inhibition
Author(s) -
Swoboda Jonathan G.,
Campbell Jennifer,
Meredith Timothy C.,
Walker Suzanne
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900557
Subject(s) - teichoic acid , biosynthesis , function (biology) , bacteria , biochemistry , microbiology and biotechnology , chemistry , biology , cell wall , peptidoglycan , enzyme , genetics
Off the wall: Wall teichoic acids (WTAs) are negatively charged glycopolymers found in dense arrays on the surface of Gram‐positive bacteria. WTAs have profound effects on the physiology of Gram‐positive organisms, and impact everything from cation homeostasis to antibiotic susceptibility to survival in a host. This review summarizes recent advances made toward understanding WTA function, biosynthesis and inhibition.