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Dynamic Sequence Modification: A Design Principle for Synthetic Informational Oligomers
Author(s) -
Diederichsen Ulf
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900543
Subject(s) - oligonucleotide , nucleobase , nucleic acid , sequence (biology) , peptide , dna , combinatorial chemistry , function (biology) , chemistry , side chain , protein engineering , amino acid , synthetic biology , peptide sequence , biochemistry , stereochemistry , computational biology , biology , organic chemistry , genetics , gene , enzyme , polymer
With thioester peptide nucleic acids a new kind of oligonucleotide analogues is pictured. The attachment of nucleobases (red) is reversible as indicated by sequence adaptability to DNA template strands (black). Amino acid side chains (green) and a regular peptide backbone (blue) in principle still allow protein‐like function. Evidence for engineering functional and informational oligomers as well as for prebiotic chemistry is discussed.