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Phosphoroselenoate Dinucleotides for Modification of mRNA 5′ End
Author(s) -
Kowalska Joanna,
Lukaszewicz Maciej,
Zuberek Joanna,
Darzynkiewicz Edward,
Jemielity Jacek
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900522
Subject(s) - messenger rna , translation (biology) , chemistry , computational biology , rna , transfer rna , computer science , biochemistry , biology , gene
Beginning from the end (5′ end) : Analogues of the messenger RNA 5′ end (cap) bearing an oxygen‐to‐selenium substitution at the β position of triphosphate bridge, which could be useful for X‐ray crystallography, were synthesised. They were also incorporated into transcripts to demonstrate that such a small change of the mRNA 5′ end can improve properties of the whole mRNA molecule, for example, its translation efficiency.