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The Global Virulence Regulators VsrAD and PhcA Control Secondary Metabolism in the Plant Pathogen Ralstonia solanacearum
Author(s) -
Schneider Patrick,
Jacobs Jonathan M.,
Neres João,
Aldrich Courtney C.,
Allen Caitilyn,
Nett Markus,
Hoffmeister Dirk
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900510
Subject(s) - ralstonia solanacearum , virulence , pathogen , secondary metabolism , biology , ralstonia , microbiology and biotechnology , human pathogen , bacteria , genetics , biosynthesis , gene
Two transcriptional regulators in the bacterium Ralstonia solanacearum (VsrAD and PhcA) that play a central role for virulence were shown to affect secondary metabolism as well; this led to the identification of a new natural product, ralfuranone. The results shed light on the regulation and biosynthetic capacities for secondary metabolism of this plant pathogen.