Premium
Eukaryotic DNA Polymerases α, β and ε Incorporate Guanine Opposite 2,2,4‐Triamino‐5(2 H )‐oxazolone
Author(s) -
Kino Katsuhito,
Sugasawa Kaoru,
Mizuno Takeshi,
Bando Toshikazu,
Sugiyama Hiroshi,
Akita Masaki,
Miyazawa Hiroshi,
Hanaoka Fumio
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900492
Subject(s) - oxazolone , guanine , chemistry , dna , dna polymerase , stereochemistry , polymerase , biochemistry , gene , nucleotide
New mechanism for G:C–C:G transversions: Here, we show for the first time that guanine is preferentially incorporated opposite 2,2,4‐triamino‐5(2 H )‐oxazolone (Oz) by eukaryotic DNA polymerases α, β, and ε. The proposed Oz:G base pair is presented.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom