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Eukaryotic DNA Polymerases α, β and ε Incorporate Guanine Opposite 2,2,4‐Triamino‐5(2 H )‐oxazolone
Author(s) -
Kino Katsuhito,
Sugasawa Kaoru,
Mizuno Takeshi,
Bando Toshikazu,
Sugiyama Hiroshi,
Akita Masaki,
Miyazawa Hiroshi,
Hanaoka Fumio
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900492
Subject(s) - oxazolone , guanine , chemistry , dna , dna polymerase , stereochemistry , polymerase , biochemistry , gene , nucleotide
New mechanism for G:C–C:G transversions: Here, we show for the first time that guanine is preferentially incorporated opposite 2,2,4‐triamino‐5(2 H )‐oxazolone (Oz) by eukaryotic DNA polymerases α, β, and ε. The proposed Oz:G base pair is presented.