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Protein Conjugates of SH3‐Domain Ligands and ATP‐Competitive Inhibitors as Bivalent Inhibitors of Protein Kinases
Author(s) -
Tiwari Rakesh,
Parang Keykavous
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900462
Subject(s) - bivalent (engine) , kinase , chemistry , conjugate , sh3 domain , biochemistry , proto oncogene tyrosine protein kinase src , mathematical analysis , mathematics , organic chemistry , metal
Double trouble : Designing bivalent inhibitors of protein kinases by using a protein (hAGT) as a spacer between SH3‐domain‐binding ligands and an ATP‐binding‐site inhibitors is described.