Regulation of Thrombin Activity with a Bifunctional Aptamer and Hemin: Development of a New Anticoagulant and Antidote Pair | Zendy

Wang Jing | Zendy; Cao Ya | Zendy; Chen Guifang | Zendy; Li Genxi | Zendy

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Regulation of Thrombin Activity with a Bifunctional Aptamer and Hemin: Development of a New Anticoagulant and Antidote Pair

Author(s) -

Wang Jing,

Cao Ya,

Chen Guifang,

Li Genxi

Publication year - 2009

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200900408

Subject(s) - hemin , antidote , aptamer , thrombin , bifunctional , chemistry , coagulation , biochemistry , thrombin generation , combinatorial chemistry , enzyme , biology , platelet , medicine , microbiology and biotechnology , organic chemistry , immunology , heme , toxicity , catalysis

Through thick and thin : A bifunctional aptamer (BA) and hemin have been designed as an anticoagulant and antidote pair. BA, as anticoagulant, inhibits thrombin by forming a BA–thrombin complex. Because of the higher affinity between hemin and BA, once hemin is added, it replaces thrombin to form a BA–hemin complex. Thrombin is then released and reactivated to exhibit blood‐clotting activity.

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