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Ergot Alkaloid Biosynthesis in Aspergillus fumigatus : FgaAT Catalyses the Acetylation of Fumigaclavine B
Author(s) -
Liu Xiaoqing,
Wang Lu,
Steffan Nicola,
Yin WenBing,
Li ShuMing
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900395
Subject(s) - aspergillus fumigatus , biosynthesis , gene cluster , acetylation , gene , biochemistry , stereochemistry , chemistry , computational biology , biology , microbiology and biotechnology
Fungal decoration : The gene fgaAT , which was identified in the biosynthetic gene cluster of fumigaclavine C in Aspergillus fumigatus , was cloned and over‐expressed in E. coli. Structure elucidation of the enzymatic product showed that FgaAT catalyses the acetylation of fumigaclavine B in the presence of acetyl coenzyme A.