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Phosphate Functional Core‐Shell Polymer Nanoparticles for the Release of Vascular Endothelial Growth Factor
Author(s) -
Gilmore Louisa,
MacNeil Sheila,
Rimmer Stephen
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900383
Subject(s) - vascular endothelial growth factor , vegf receptors , nanoparticle , angiogenesis , polystyrene , phosphate , core (optical fiber) , nanotechnology , polymer , chemistry , peptide , computer science , computational biology , combinatorial chemistry , biochemistry , materials science , biology , cancer research , organic chemistry , telecommunications
Nanodelivery : The controlled delivery of growth factors is an essential aspect of angiogenesis, and here we describe a particulate delivery system that provides vascular endothelial growth factor (VEGF). Core‐shell nanoparticles composed of polystyrene cores and cross‐linked polymers of an alkenyl phosphate bind and release VEGF and highly basic peptide sequences. VEGF was released over several days in a bioactive form.