SSB‐Assisted Duplex Invasion of Preorganized PNA into Double‐Stranded DNA | Zendy

Ishizuka Takumi | Zendy; Tedeschi Tullia | Zendy; Corradini Roberto | Zendy; Komiyama Makoto | Zendy; Sforza Stefano | Zendy; Marchelli Rosangela | Zendy

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SSB‐Assisted Duplex Invasion of Preorganized PNA into Double‐Stranded DNA

Author(s) -

Ishizuka Takumi,

Tedeschi Tullia,

Corradini Roberto,

Komiyama Makoto,

Sforza Stefano,

Marchelli Rosangela

Publication year - 2009

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200900381

Subject(s) - duplex (building) , circular dichroism , dna , single strand , stereochemistry , chemistry , computational biology , biophysics , biology , crystallography , microbiology and biotechnology , genetics , biochemistry

Invasion of the DNA snatchers : We show that one strand of decamer D K α ‐PNA efficiently invades into double‐stranded DNA (dsDNA) by utilizing the SSB‐assisted duplex invasion. An extensive analysis of D K α ‐PNA–DNA duplex formation performed by calculation of the thermodynamic parameters and circular dichroism experiments ascertained that a right‐handed helical preorganization is a very important contribution when one PNA strand invades into dsDNA.

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