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Amyloids Go Genomic: Insights Regarding the Sequence Determinants of Prion Formation from Genome‐Wide Studies
Author(s) -
Lashuel Hilal A.,
Pappu Rohit V.
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900373
Subject(s) - genome , sequence (biology) , computational biology , biology , amyloid (mycology) , whole genome sequencing , organism , genetics , gene , botany
Build up? The availability of fully sequenced genomes provides a useful starting point for identifying putative amyloid‐ and prion‐forming sequences through genome‐wide scans. With an inventory in hand, one can assess the amyloid‐forming potential and the functional consequences of amyloid formation for each sequence, thus advancing our understanding of how cells process and utilize deleterious and functional aggregates, respectively.