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A RNA‐Based Approach towards Small‐Molecule Inhibitors
Author(s) -
Mayer Günter,
Faulhammer Dirk,
Grättinger Mira,
Fessele Sabine,
Blind Michael
Publication year - 2009
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200900325
Subject(s) - aptamer , small molecule , computational biology , identification (biology) , rna , chemistry , chemical biology , combinatorial chemistry , computer science , biology , biochemistry , gene , genetics , botany
Apt for the job : The identification of low‐molecular‐weight protein inhibitors for functional studies as well as for the generation of lead drug compounds is one of the most important tasks in chemical biology. We describe a generalized assay that utilizes inhibitory aptamers for the identification of small molecules with aptamer‐inherited properties. These compounds share the functional profile of the aptamers and thus are considered as potent protein inhibitors.